What is radiotherapy and what does it do?
Radiotherapy,
together with conventional surgery, is one of the most common cancer treatment
options available. Radiation can shrink a tumor by killing tumor cells or
interfering with the tumor’s ability to grow. With conventional radiotherapy the
radiation dose needed to destroy the tumor is applied in low doses during many
sessions.
An effective radiation delivery method used in radiotherapy is Intensity
Modulated Radiation Therapy (IMRT). During IMRT the radiation dose is
matched to the three-dimensional shape of a patient’s lesion, focusing higher
radiation doses on the tumor while minimizing exposure to healthy tissue
surrounding the treatment area. IMRT utilizes multiple radiation beams from more
than one direction that constantly adjust to achieve the three-dimensional shape
of the tumor.
Radiation therapy stops tumor cells from growing and dividing. In many cases
radiation therapy can effectively kill cancer cells by shrinking or eliminating
the tumor all together.
One of the most important steps on the way to improve radiotherapy was the
introduction of computed tomography with direct applications within treatment
planning. This new imaging technique, coupled with improvements in computer
processing capabilities and speed, meant computer planning systems rapidly
developed to allow individualized patient planning in 3 dimensions. This was
followed by the introduction of multi-leaf collimators, which resulted in an
increase in the conformality of the dose distribution achievable around the
treatment target.
How is image-guided radiotherapy (IGRT) superior to other
methods?
More sophisticated methods of planning and beam delivery are now available in
the form of intensity modulated radiotherapy, IMRT in which the intensity of the
radiation is varied during radiation beam delivery. This enables better sparing
of organs at risk and the possibility of escalating the dose to the target
without compromising surrounding healthy tissue. This benefit can only be fully
realized if the radiation distribution is assured to be delivered where it is
planned in relation to patient structures.
Image-guided
radiotherapy (IGRT) uses imaging techniques to improve the accuracy of
radiotherapy delivery to the target tumor, allowing more accurate and precise
targeting of the treatment volume and avoidance of organs at risk. This may lead
to a reduction in the radiation-induced complications and side effects that are
caused by irradiation of normal tissues. It may also allow an increased dose to
be delivered to the target tissues, thereby maximizing the chances of successful
control or eradication of the tumor.
Image-guided radiotherapy (IGRT) improves the radiotherapy treatment in the
following ways:
- To visualize the anatomical target and organs at risk in 3D
- To identify changes in position, shape and size of target anatomy relative to that seen when the treatment was planned
- To quantify the variation in position of the anatomical target between the planned and initial setup treatment images
- To correct any patient misalignment by changing the relative geometry of the treatment machine before the treatment is delivered.
What is the Image-Guided Radiotherapy (IGRT) Unit Comprised
of?
The typical image-guided
radiotherapy (IGRT) system is a kV-cone beam CT system integrated onto a
precise linear accelerator. The system consists of an X-ray tube and amorphous
silicon flat panel detector both of which are mounted with a view direction that
is perpendicular to the treatment beam axis. The tube is deployed for imaging
while the detector unfolds from its stored position against the face of the
gantry under motorized control. The configuration of the system has the X-ray
source at 1000 mm from the machine’s isocenter, which is the same standard
distance of the therapeutic source to the isocenter.
There is also another, technically different, approach to image-guided
radiotherapy (IGRT): Tomotherapy is a new way of
delivering radiation treatment for cancer and literally means “slice therapy”.
The tomotherapy system can deliver small beamlets of radiation from every point
on a spiral, providing exceptional accuracy.
The more angles that a radiation treatment beam can be delivered from, the
better the focus on the tumor and the less effect on surrounding tissue.
What makes tomotherapy truly revolutionary, however, is the ability to create
a computed tomography (CT) image just prior to radiation treatment. This means
that we can now view a full three-dimensional image of a patient’s anatomy and
adjust the size, shape and intensity of the radiation beam to the precise
location of the patient’s tumor.
Source: http://www.medwow.com/articles/
tags: Tomotherapy , image-guided radiotherapy (IGRT) , Intensity Modulated Radiation Therapy (IMRT) , Radiotherapy , imaging equipment, Radiology