The Non-Invasive Advantage
There is no doubt that pulse
oximetry represents a great advance in patient monitoring. It is a
relatively inexpensive and above all, completely non-invasive technique.
Pulse oximetry is a
continuous and non-invasive method of measuring the level of arterial oxygen
saturation in blood. The measurement is taken by placing a sensor on a patient,
usually on the fingertip for adults, and the hand or foot for infants. The
sensor is connected to the pulse oximetry instrument with a patient cable. The
pulse oximetry sensor collects signal data from the patient and sends it to the
instrument. The instrument displays the calculated data in three ways:
- As a percent value for arterial oxygen saturation (SpO2).
- As a pulse rate (PR).
- As a plethysmographic waveform.
The Evolution of Pulse Oximetry
Development of non-invasive spectrophotometric techniques to monitor
O2 saturation began during World War II. The development of high
altitude aircraft created a need for pilots to be externally monitored for any
physiological changes induced by extreme altitude. In response to this need, the
first functional non-invasive spectrophotometer was developed in 1942. Its
inventor, Glen Millikan, named this new device the “oximeter”.
Pulse oximeters have evolved from physiologic monitoring curiosities to
common patient monitoring
devices. New pulse oximetry technology couples spectrophotometry with pulse
waveform monitoring and permits clinicians to continuously assess arterial
O2 saturation in operating rooms, in intensive care units, during
sleep studies (polysomnography), and at the bedside. Portable pulse oximeters
and recorders have also become popular monitoring devices during emergency
medical transport and outpatient assessment of gas exchange. Advantages to pulse
oximeters, other than their non-invasiveness, include their well-documented
accuracy, ease-of-application, and good patient tolerance.
Pulse Oximetry’s Abilities
Continuous pulse oximetric monitoring of arterial oxygenation can detect
intermittent or chronic disruptions in gas exchange that may not be detected by
random arterial blood sampling and analysis. Also, pulse oximeter measurements
of O2 saturation do not carry the risk of morbidity and mortality
associated with invasive arterial blood sampling. Another value of continuous
monitoring is the ability to quantitatively determine the amount of time spent
at any given level of arterial O2 saturation. This information can
then be used to monitor the progression of gas exchange impairment or to
evaluate the effectiveness of therapeutic interventions. With such widespread
application of pulse oximetry technology, comprehension of the operating
principles and the practical limitations of use can aid clinicians. The
following section describes the fundamental principles used in pulse oximetry
technology to acquaint clinicians with environmental and physiological
conditions that can affect their use.
The Measurement Process
The measurement process is based on two factors:
- A pulsatile signal is generated by the heart in arterial blood, which is not present in venous blood and other tissues.
- Oxyhemoglobin and reduced hemoglobin have different absorption spectra. Also, it is important to note that both spectra are within the optical window of water (and the soft tissue).
Pulse oximeters measure oxygen saturation by means of a sensor attached to
the patient’s finger, toe, nose, earlobe or forehead. Typically, the sensor uses
two light-emitting diodes (LEDs) at wavelengths of 660nm and 940 nm (infrared)
and a photodetector placed opposite them. The photodetector measures the amount
of red and infrared light that passes through the tissue to determine the
quantity of light absorbed by the oxyhemoglobin and hemoglobin. As the
proportion of oxyhemoglobin increases in the blood, the absorbance of the red
wavelength decreases, while the absorption of infrared increases.
SpO2 is determined by calculating the ratio of red-to-infrared light
absorbencies and comparing it with values in a look-up table or calibration
curve, which is a standardized curve developed empirically by simultaneous
measurement of SaO2 and light absorbencies.
SpO2 is physiologically related to arterial oxygen tension
(PaO2) according to the O2Hb dissociation curve. Because
the O2Hb dissociation curve has a sigmoid shape, oximetry is
relatively insensitive in the detection of developing hypoxemia in patients with
high baseline PaO2.
SpO2 measurements made by a pulse oximeter are defined as being
accurate if the root-mean-square (RMS) difference is less than or equal to 4.0%
SpO2 over the arterial oxygen saturation (SaO2) range of
70% to 100%, SpO2 accuracy should be determined by clinical study of
healthy or sick subjects, whereby SpO2 measurements are compared
with SaO2 measurements.
Other Pulse Oximeter Factors
Pulse oximeters can also measure pulse rate. The standard states that pulse
rate accuracy should be defined as the RMS difference between paired pulse data
recorded with pulse oximeter and a reference method.
There are several limitations of pulse oximetry:
skin pigmentation, ambient light, intravenous dyes, low perfusion and motion
artifact.
As pulse oximetry technology has advanced, manufacturers have attempted to
reduce the effect of some of the limitations mentioned above. Particular
improvements have been made in the ability of oximeters to deal with low
signal-to-noise conditions observed during periods of motion or low
perfusion.
Regular functional checks should be carried out on equipment to ensure it is
safe to use. This should include visual checks, especially checking for signs of
damage.
Functionality of an oximeter can be checked using a pulse oximeter tester or
simulator. These simulate the properties of a finger and its pulsatile blood
flow. Their purpose is allowing testing of a pulse oximeter and the continuity
of probes. They cannot be used to validate the accuracy of a pulse
oximeter.
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